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You can treat chronic pain and psychological symptoms such anxiety, anger, and mood instability without medications. Jokes can be used for the same purpose, because laughter releases endorphins, which are natural opioids produced by the brain.

Endogenous opioids have the same effects as pharmaceutical opioids so you dont need pharmaceuticals to treat psychiatric symptoms because human body produces its own drugs that make you high. Wikipedia claims that beta endorphin has 80 times greater potency than morphine and binds to same receptors in the brain and it also has very similar chemical structure to morphine. In fact word endorphin actually means "endogenous morphine". Other hormones that can make you high are serotonin, oxytocin, dopamine, adrenaline. Serotonin is released when you take antidepressants such as Prozac, oxytocin is released when you take MDMA which also known as street drug "Ecstasy", dopamine is released when take Cocaine. These hormones form the basis of behavioral addictions such as pathological gambling, Internet addiction, video-game addiction and sex addiction. So other ways to release these natural drugs are exercise, having sex(very effective), listening to favorite music, use of flotation tanks, playing video-games and so on.

Other more extreme ways are based on research of doctor Rick Strassman that suggest that pineal gland in the brain produces endogenous psychedelic tryptamine DMT and that utilizing special exercises you can release this chemical that can propel you to other worlds :D

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